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DiscoveryProbe™ Cell Cycle Library
449个细胞周期相关化合物的集合，用于细胞周期研究
文献引用
1. Huang T, Ding X, et al. "CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL-XL inhibitor ABT-263." Cell Death Dis. 2019 Aug 9;10(8):602. PMID:31399555
Featured Products of the Library
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles |
| A1723 | Roscovitine (Seliciclib,CYC202) | CDK inhibitor,potent and selective | Cyclin-Dependent Kinases | 186692-46-6 | CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C |
| A3965 | BI 2536 | Plk1 inhibitor,potent and ATP-competitive | PLK | 755038-02-9 | CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C |
| A4118 | Hesperadin | Aurora B kinase inhibitor | Aurora Kinase | 422513-13-1 | CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5 |
| A4605 | KU 55933 | ATM inhibitor,potent and selective | ATM/ATR | 587871-26-9 | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 |
| A5755 | MK-1775 | Wee1 kinase inhibtor,potent and ATP-competitive | Wee1 | 955365-80-7 | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O |
| A8316 | PD 0332991 (Palbociclib) HCl | CDK4/6 inhibitor,highly selective | Cyclin-Dependent Kinases | 827022-32-2 | O=C1N(C2=NC(NC3=NC=C(C=C3)N4CCNCC4)=NC=C2C(C)=C1C(C)=O)C5CCCC5.Cl |
| A8336 | KU-60019 | ATM kinase inhibitor,potent and selective | ATM/ATR | 925701-49-1 | CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6 |
| A8882 | THZ1 | Covalent CDK7 inhibitor,potent and selective | Cyclin-Dependent Kinases | 1604810-83-4 | ClC1=CN=C(N=C1C2=CNC3=CC=CC=C23)NC4=CC=CC(NC(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)=C4 |