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GDNF, Mouse
概述 
| Synonyms | Glial-Derived Neurotrophic Factor, ATF-1 |
| Description | Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption. |
| Accession No | P48540 |
| Species | Mouse |
| Source | CHO |
| Biological Activity | ED50 <8μg /ml, measured in a bioassay using C6 cells. |
| Sequence | MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR |
特性
| Measured Molecular Weight | 17-22 kDa, observed by reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE and HPLC. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant murine GDNF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Note | For research use only |