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Thymosin β 4, Human
概述 
| Synonyms | Tβ4 Human; |
| Description | Thymosin Beta 4 is a naturally occurring peptide. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. Tβ4 is not a growth factor; rather, it is a major actin regulating peptide. The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue. |
| Species | Human |
| Source | E. coli |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 μg/ml. |
| Sequence | SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA |
特性
| Measured Molecular Weight | Approximately 4.9 kDa, a single non-glycosylated polypeptide chain containing 43 amino acids. |
| Purity | > 97 % by SDS-PAGE and HPLC analyses. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Endotoxin Level | Less than 1 EU/μg of rHuTβ4 as determined by LAL method. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Storage | This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles. |
| Note | ; |