ZRANB3 Polyclonal Antibody

Applications

Tested Applications:

IF, IHC, WB, ELISA

Species specificity:

human

Positive WB detected in:

HEK-293 cells

Positive IHC detected in:

human kidney tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Positive IF detected in:

HEK-293 cells

Recommended dilution:

WB : 1:500-1:1000

IHC : 1:50-1:500

IF : 1:20-1:200

Product Information

Source:

Rabbit

Purification method:

Antigen affinity purification

Isotype:

IgG

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:

ZRANB3 fusion protein Ag19407

Full name:

zinc finger, RAN-binding domain containing 3

Calculated molecular weight:

1079 aa, 123 kDa

Observed molecular weight:

150 kDa

Gene symbol

ZRANB3

Synonyms

ZRANB3

Background

ZRANB3, also named Annealing helicase 2 or DNA annealing helicase and endonuclease ZRANB3, is a 1079 amino acid protein, which contains one RanBP2-type zinc finger, one helicase C-terminal domain, one HNH domain and one helicase ATP-binding domain. ZRANB3 localizes in the nucleus and belongs to the SNF2/RAD54 helicase family. ZRANB3 as a DNA annealing helicase and endonuclease is required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events.